Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P63128
UPID:
POK9_HUMAN
Alternative names:
HERV-K(C6) Gag-Pol protein; HERV-K109 Gag-Pol protein; HERV-K_6q14.1 provirus ancestral Gag-Pol polyprotein
Alternative UPACC:
P63128; Q9UKH4
Background:
The Endogenous retrovirus group K member 9 Pol protein, known by alternative names such as HERV-K(C6) Gag-Pol protein and HERV-K109 Gag-Pol protein, plays a pivotal role in the viral replication cycle. It is involved in assembly, budding, maturation, and infection stages, facilitating membrane associations, self-associations, and packaging of genomic RNA. Its reverse transcriptase and integrase functions are crucial for converting viral RNA into DNA and integrating it into the host cell chromosome.
Therapeutic significance:
Understanding the role of Endogenous retrovirus group K member 9 Pol protein could open doors to potential therapeutic strategies.