Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P63136
UPID:
POK25_HUMAN
Alternative names:
HERV-K_11q22.1 provirus ancestral Pol protein
Alternative UPACC:
P63136
Background:
The Endogenous retrovirus group K member 25 Pol protein, also known as HERV-K_11q22.1 provirus ancestral Pol protein, plays a crucial role in the early stages of infection. It converts viral RNA into double-stranded DNA, with its RNase H domain degrading the RNA template and removing the RNA primer. This protein is also involved in the integration of viral DNA into the host cell chromosome, a process facilitated by the integrase.
Therapeutic significance:
Understanding the role of Endogenous retrovirus group K member 25 Pol protein could open doors to potential therapeutic strategies.