Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P78371
UPID:
TCPB_HUMAN
Alternative names:
CCT-beta
Alternative UPACC:
P78371; A8K402; B5BTY7; B7Z243; B7Z7K4; B7ZAT2; Q14D36; Q6IAT3
Background:
T-complex protein 1 subunit beta (CCT-beta) is a crucial component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex vital for protein folding upon ATP hydrolysis. This complex is instrumental in the folding of WRAP53/TCAB1, influencing telomere maintenance, and plays a role in ciliogenesis by assisting in the assembly of the BBSome complex. Additionally, the TRiC complex is involved in the folding of key cellular structures such as actin and tubulin.
Therapeutic significance:
Understanding the role of T-complex protein 1 subunit beta could open doors to potential therapeutic strategies.