Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P78382
UPID:
S35A1_HUMAN
Alternative names:
Solute carrier family 35 member A1
Alternative UPACC:
P78382; Q5W1L8
Background:
The CMP-sialic acid transporter, also known as Solute carrier family 35 member A1, plays a pivotal role in cellular function by transporting CMP-sialic acid from the cytosol into the Golgi apparatus. This process is crucial for the proper glycosylation of proteins, a post-translational modification essential for protein stability and function. The transporter operates as an antiporter, exchanging CMP-sialic acid for CMP, and demonstrates a higher affinity for free CMP. Additionally, it facilitates the transport of CDP-ribitol, underscoring its versatility in cellular transport mechanisms.
Therapeutic significance:
Given its critical role in protein N-glycosylation, the CMP-sialic acid transporter is directly implicated in Congenital disorder of glycosylation 2F, a severe inherited disease characterized by a broad spectrum of clinical features including developmental disorders and immunodeficiency. Understanding the role of this transporter could open doors to potential therapeutic strategies aimed at correcting glycosylation defects.