Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P78406
UPID:
RAE1L_HUMAN
Alternative names:
Rae1 protein homolog; mRNA-associated protein mrnp 41
Alternative UPACC:
P78406; A8K882; O15306; Q3SYL7; Q5TCH8; Q6V708; Q9H100; Q9NQM6
Background:
The mRNA export factor RAE1, also known as Rae1 protein homolog and mRNA-associated protein mrnp 41, is pivotal in nucleocytoplasmic transport, as evidenced by its role in mRNA export (PubMed:33849972, PubMed:20498086). Additionally, RAE1 contributes to mitotic bipolar spindle formation and may facilitate the attachment of cytoplasmic mRNPs to the cytoskeleton (PubMed:17172455).
Therapeutic significance:
Understanding the role of mRNA export factor RAE1 could open doors to potential therapeutic strategies.