Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
It features thorough molecular simulations of the receptor within its native membrane environment, complemented by ensemble virtual screening that considers its conformational mobility. For dimeric or oligomeric receptors, the full functional complex is constructed, and tentative binding sites are determined on and between the subunits to cover the entire spectrum of potential mechanisms of action.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P78556
UPID:
CCL20_HUMAN
Alternative names:
Beta-chemokine exodus-1; CC chemokine LARC; Liver and activation-regulated chemokine; Macrophage inflammatory protein 3 alpha; Small-inducible cytokine A20
Alternative UPACC:
P78556; Q53S51; Q99664
Background:
C-C motif chemokine 20, known by various names such as Beta-chemokine exodus-1 and Liver and activation-regulated chemokine, plays a pivotal role in immune responses. It acts as a ligand for CCR6, inducing chemotaxis of dendritic cells, T-cells, and B-cells, crucial for immune surveillance and response. Its ability to mobilize calcium ions and regulate sperm motility underscores its diverse biological functions.
Therapeutic significance:
Given its central role in mediating immune cell migration and involvement in inflammatory conditions, C-C motif chemokine 20 is a prime candidate for therapeutic intervention in autoimmune diseases and cancer. Understanding the role of C-C motif chemokine 20 could open doors to potential therapeutic strategies.