Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P82921
UPID:
RT21_HUMAN
Alternative names:
28S ribosomal protein S21, mitochondrial
Alternative UPACC:
P82921; A0A075B746; Q5TB11; Q9BST6
Background:
The Small ribosomal subunit protein bS21m, also known as 28S ribosomal protein S21, mitochondrial, plays a crucial role in the mitochondrial ribosome. It is involved in the translation of mitochondrial DNA-encoded proteins, essential for mitochondrial function and energy production. Its unique position in the mitochondrial ribosome makes it a key player in cellular energy metabolism.
Therapeutic significance:
Understanding the role of Small ribosomal subunit protein bS21m could open doors to potential therapeutic strategies. Its critical function in energy production suggests that targeting this protein could offer new avenues for treating diseases related to mitochondrial dysfunction.