Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P83105
UPID:
HTRA4_HUMAN
Alternative names:
High-temperature requirement factor A4
Alternative UPACC:
P83105; Q542Z4; Q6PF13
Background:
Serine protease HTRA4, also known as High-temperature requirement factor A4, is a protein that plays a crucial role in various biological processes through its serine protease activity. This enzyme is involved in the degradation of misfolded proteins, signaling pathways, and cellular homeostasis, showcasing its importance in maintaining cellular integrity and function.
Therapeutic significance:
Understanding the role of Serine protease HTRA4 could open doors to potential therapeutic strategies. Its involvement in critical cellular processes highlights its potential as a target for drug discovery, aiming to modulate its activity in disease contexts where its function may be dysregulated.