Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P86452
UPID:
ZBED6_HUMAN
Alternative names:
-
Alternative UPACC:
P86452
Background:
Zinc finger BED domain-containing protein 6 plays a crucial role in transcriptional repression, binding to specific sequences to regulate gene expression. It is pivotal in controlling the expression of genes like IGF2 and PGAP6/TMEM8, impacting muscle and organ growth, myoblast differentiation, and mitochondrial activity. This protein also influences the cell cycle and survival of pancreatic beta cells, with implications for cell adhesion and embryonic beta cell differentiation.
Therapeutic significance:
Understanding the role of Zinc finger BED domain-containing protein 6 could open doors to potential therapeutic strategies.