AI-ACCELERATED DRUG DISCOVERY

Focused On-demand Library for Solute carrier family 25 member 3

Available from Reaxense
Predicted by Alphafold

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.

We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.

The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.

We use our state-of-the-art dedicated workflow for designing focused libraries.

 Fig. 1. The sreening workflow of Receptor.AI

Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.

Our library distinguishes itself through several key aspects:

  • The Receptor.AI platform integrates all available data about the target protein, including past experiments, literature data, known ligands, structural information and more. This consolidated approach maximises the probability of prioritising highly relevant compounds.
  • The platform uses sophisticated molecular simulations to identify possible binding sites so that the compounds in the focused library are suitable for discovering allosteric inhibitors and the binders for cryptic pockets.
  • The platform integrates over 50 highly customisable AI models, which are thoroughly tested and validated on a multitude of commercial drug discovery programs and research projects. It is designed to be efficient, reliable and accurate. All this power is utilised when producing the focused libraries.
  • In addition to producing the focused libraries, Receptor.AI provides services and end-to-end solutions at every stage of preclinical drug discovery. The pricing model is success-based, which reduces your risks and leverages the mutual benefits of the project's success.

partner

Reaxense

upacc

Q00325

UPID:

S25A3_HUMAN

Alternative names:

Phosphate carrier protein, mitochondrial; Phosphate transport protein

Alternative UPACC:

Q00325; B3KS34; Q7Z7N7; Q96A03

Background:

The Solute Carrier Family 25 Member 3, also known as the Phosphate Carrier Protein, mitochondrial, plays a crucial role in transporting phosphate or copper ions across the mitochondrial inner membrane. It is essential for mitochondrial oxidative phosphorylation, which converts ADP to ATP, and for maintaining the mitochondrial matrix copper pool necessary for cytochrome C oxidase complex assembly.

Therapeutic significance:

Mitochondrial phosphate carrier deficiency, a disorder linked to this protein, is characterized by lactic acidosis, hypertrophic cardiomyopathy, and muscular hypotonia, leading to early mortality. Understanding the role of Solute Carrier Family 25 Member 3 could open doors to potential therapeutic strategies for this and related mitochondrial disorders.

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