Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q01118
UPID:
SCN7A_HUMAN
Alternative names:
Putative voltage-gated sodium channel subunit alpha Nax; Sodium channel protein cardiac and skeletal muscle subunit alpha; Sodium channel protein type VII subunit alpha
Alternative UPACC:
Q01118
Background:
The Sodium channel protein type 7 subunit alpha, also known as Putative voltage-gated sodium channel subunit alpha Nax, plays a crucial role in mediating the voltage-dependent sodium ion permeability of excitable membranes. This protein transitions between opened or closed conformations based on the voltage difference across the membrane, forming a sodium-selective channel that facilitates Na(+) ions passage in line with their electrochemical gradient.
Therapeutic significance:
Understanding the role of Sodium channel protein type 7 subunit alpha could open doors to potential therapeutic strategies.