Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q01970
UPID:
PLCB3_HUMAN
Alternative names:
Phosphoinositide phospholipase C-beta-3; Phospholipase C-beta-3
Alternative UPACC:
Q01970; A5PKZ6; G5E960; Q8N1A4
Background:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, also known as Phosphoinositide phospholipase C-beta-3 and Phospholipase C-beta-3, plays a crucial role in cell signaling by generating diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). These second messenger molecules are pivotal in transmitting signals from various growth factors and hormones.
Therapeutic significance:
This protein's mutation is linked to Spondylometaphyseal dysplasia with corneal dystrophy, a disorder affecting growth, limb development, and intellectual ability. Understanding the role of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 could open doors to potential therapeutic strategies for this and related conditions.