Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q02153
UPID:
GCYB1_HUMAN
Alternative names:
Guanylate cyclase soluble subunit beta-3; Soluble guanylate cyclase small subunit
Alternative UPACC:
Q02153; B7Z426; Q86WY5
Background:
The Guanylate cyclase soluble subunit beta-1, also known as Guanylate cyclase soluble subunit beta-3 and Soluble guanylate cyclase small subunit, plays a pivotal role in cellular signaling. It mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP, a critical process in various physiological pathways.
Therapeutic significance:
Understanding the role of Guanylate cyclase soluble subunit beta-1 could open doors to potential therapeutic strategies. Its central function in NO signaling pathways suggests its involvement in critical physiological processes, making it a target of interest in drug discovery.