Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q02487
UPID:
DSC2_HUMAN
Alternative names:
Cadherin family member 2; Desmocollin-3; Desmosomal glycoprotein II; Desmosomal glycoprotein III
Alternative UPACC:
Q02487
Background:
Desmocollin-2, known by alternative names such as Cadherin family member 2, Desmocollin-3, Desmosomal glycoprotein II, and III, plays a crucial role in cell-cell adhesion. It is a component of intercellular desmosome junctions, facilitating the interaction between plaque proteins and intermediate filaments. This protein is pivotal in mediating differential adhesiveness among cells, contributing to epidermal cell positioning and stratification.
Therapeutic significance:
Desmocollin-2's involvement in Arrhythmogenic right ventricular dysplasia, familial, 11, a congenital heart disease, underscores its therapeutic significance. Understanding the role of Desmocollin-2 could open doors to potential therapeutic strategies for treating ventricular and supraventricular arrhythmias.