Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q02577
UPID:
HEN2_HUMAN
Alternative names:
Class A basic helix-loop-helix protein 34; Nescient helix loop helix 2
Alternative UPACC:
Q02577; Q5T1P6
Background:
Helix-loop-helix protein 2, also known as Class A basic helix-loop-helix protein 34 or Nescient helix loop helix 2, plays a pivotal role in energy expenditure, body mass regulation, and reproductive longevity. It acts as a transcriptional activator of genes such as NDN, PCSK1, MC4R, and KISS1, influencing the hypothalamic-pituitary-gonadal axis and adipose tissue function.
Therapeutic significance:
Linked to Hypogonadotropic hypogonadism 27 without anosmia, Helix-loop-helix protein 2's understanding could pave the way for novel therapeutic strategies targeting reproductive and metabolic disorders.