Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q03113
UPID:
GNA12_HUMAN
Alternative names:
-
Alternative UPACC:
Q03113; A4D204; B3KXS2; B7Z3F7; Q2T9L1; Q5PPR5; Q86UM8; Q8TD71; Q9UDU9
Background:
Guanine nucleotide-binding protein subunit alpha-12 (GNA12) plays a pivotal role in modulating transmembrane signaling systems. It activates the effector molecule RhoA, regulating transcription factor AP-1 and protein phosphatase 2A activation. GNA12's involvement extends to promoting tumor cell invasion, metastasis through RhoA/ROCK signaling, and modulating pro-inflammatory cytokine production. Additionally, it influences cell adhesion and CDH5 plasma membrane localization.
Therapeutic significance:
Understanding the role of Guanine nucleotide-binding protein subunit alpha-12 could open doors to potential therapeutic strategies. Its critical function in signaling pathways and cell behavior modulation highlights its potential as a target in treating diseases related to cell invasion, metastasis, and inflammation.