Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q03395
UPID:
ROM1_HUMAN
Alternative names:
Tetraspanin-23
Alternative UPACC:
Q03395; B2R978
Background:
Rod outer segment membrane protein 1, also known as Tetraspanin-23, is pivotal in retinal health, facilitating rod outer segment (ROS) morphogenesis and maintaining the retina's outer nuclear layer. Its collaboration with PRPH2 ensures the structural integrity of ROS curved disks, crucial for vision.
Therapeutic significance:
Linked to Retinitis pigmentosa 7, a progressive retinal dystrophy, understanding Tetraspanin-23's function could unveil new therapeutic avenues. Its role in ROS maintenance and disk diameter regulation highlights its potential in retinal disease treatment strategies.