Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q05066
UPID:
SRY_HUMAN
Alternative names:
Testis-determining factor
Alternative UPACC:
Q05066
Background:
The Sex-determining region Y protein, also known as Testis-determining factor, is a pivotal transcriptional regulator in male development. It orchestrates the genetic switch necessary for male sex determination by guiding the development of supporting cell precursors as Sertoli cells. This protein binds to specific DNA sequences, promoting gene activation or repression, and is also involved in pre-mRNA splicing. Its role extends to the maintenance of motor functions in dopaminergic neurons in the male brain.
Therapeutic significance:
Given its crucial role in sex determination and association with conditions such as 46,XY sex reversal 1 and 46,XX sex reversal 1, the Sex-determining region Y protein presents a significant target for therapeutic intervention. Understanding the role of this protein could open doors to potential therapeutic strategies for sex reversal conditions.