Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q06710
UPID:
PAX8_HUMAN
Alternative names:
-
Alternative UPACC:
Q06710; Q09155; Q16337; Q16338; Q16339; Q4ZG35; Q96J49
Background:
Paired box protein Pax-8 plays a pivotal role in thyroid cell differentiation and regulation of thyroid-specific gene expression. Its unique function ensures the proper development and function of the thyroid gland, a critical component in the body's endocrine system.
Therapeutic significance:
Given its crucial role in thyroid development, mutations in Pax-8 are directly linked to Hypothyroidism, congenital, non-goitrous, 2, a condition marked by thyroid dysgenesis. Understanding the role of Paired box protein Pax-8 could open doors to potential therapeutic strategies for congenital hypothyroidism.