Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q06828
UPID:
FMOD_HUMAN
Alternative names:
Collagen-binding 59 kDa protein; Keratan sulfate proteoglycan fibromodulin
Alternative UPACC:
Q06828; Q15331; Q8IV47
Background:
Fibromodulin, also known as collagen-binding 59 kDa protein or keratan sulfate proteoglycan fibromodulin, plays a crucial role in the body's connective tissue. It affects the rate of fibrils formation and is believed to have a primary role in collagen fibrillogenesis. This protein's interaction with collagen highlights its importance in maintaining the structural integrity of various tissues.
Therapeutic significance:
Understanding the role of Fibromodulin could open doors to potential therapeutic strategies. Its involvement in collagen fibrillogenesis suggests that targeting Fibromodulin could lead to advancements in treating diseases related to connective tissue disorders.