Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q07283
UPID:
TRHY_HUMAN
Alternative names:
-
Alternative UPACC:
Q07283; Q5VUI3
Background:
Trichohyalin, an intermediate filament-associated protein, plays a crucial role in hair and skin structure. It binds with keratin intermediate filaments in hair follicles and epidermis, contributing to cell envelope organization and anchoring. Its involvement in calcium-dependent processing during cell differentiation highlights its importance in tissue integrity.
Therapeutic significance:
Understanding the role of Trichohyalin could open doors to potential therapeutic strategies, especially considering its link to Uncombable hair syndrome 3. This connection suggests that targeting Trichohyalin's function or its genetic variants could offer new avenues for treating or managing this and potentially other related dermatological conditions.