Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q07866
UPID:
KLC1_HUMAN
Alternative names:
-
Alternative UPACC:
Q07866; A6NF62; F8VTM4; Q7RTM2; Q7RTM3; Q7RTM5; Q7RTP9; Q7RTQ3; Q7RTQ5; Q7RTQ6; Q86SF5; Q86TF5; Q86V74; Q86V75; Q86V76; Q86V77; Q86V78; Q86V79; Q96H62
Background:
Kinesin light chain 1 is a pivotal component of the kinesin motor complex, known for its essential role in microtubule-associated, force-producing movements. This protein is crucial for the transport of organelles within cells, as highlighted in recent research (PubMed:21385839). Its light chain is particularly significant for linking cargo to the heavy chain and modulating ATPase activity, facilitating efficient intracellular transport.
Therapeutic significance:
Understanding the role of Kinesin light chain 1 could open doors to potential therapeutic strategies. Its fundamental involvement in cellular transport mechanisms positions it as a key target for interventions in diseases where intracellular movement is compromised.