Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q07912
UPID:
ACK1_HUMAN
Alternative names:
Tyrosine kinase non-receptor protein 2
Alternative UPACC:
Q07912; Q6ZMQ0; Q8N6U7; Q96H59
Background:
Activated CDC42 kinase 1, also known as Tyrosine kinase non-receptor protein 2, plays a pivotal role in various cellular processes including cell migration, survival, growth, and proliferation. It acts by phosphorylating key proteins such as AKT1, AR, and EGFR, influencing both cytosolic and nuclear signaling pathways. Its interaction with CDC42 highlights its importance in cell migration, emphasizing its role in synaptic function and brain development.
Therapeutic significance:
Understanding the role of Activated CDC42 kinase 1 could open doors to potential therapeutic strategies. Its involvement in critical signaling pathways and cell processes underscores its potential as a target for drug discovery, aiming to modulate its activity for therapeutic benefits.