Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q08043
UPID:
ACTN3_HUMAN
Alternative names:
Alpha-actinin skeletal muscle isoform 3; F-actin cross-linking protein
Alternative UPACC:
Q08043; A6NP77; Q4KKV2
Background:
Alpha-actinin-3, known as a skeletal muscle isoform and F-actin cross-linking protein, plays a crucial role in anchoring actin to various intracellular structures. This protein is essential for the bundling of actin filaments, contributing to the structural integrity and contractile properties of muscle cells.
Therapeutic significance:
Understanding the role of Alpha-actinin-3 could open doors to potential therapeutic strategies. Its pivotal function in muscle architecture and dynamics positions it as a key target for interventions aimed at enhancing muscle function and treating muscle-related disorders.