Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q08211
UPID:
DHX9_HUMAN
Alternative names:
DEAH box protein 9; DExH-box helicase 9; Leukophysin; Nuclear DNA helicase II; RNA helicase A
Alternative UPACC:
Q08211; B2RNV4; Q05CI5; Q12803; Q32Q22; Q5VY62; Q6PD69; Q99556
Background:
ATP-dependent RNA helicase A, also known as DEAH box protein 9, plays a pivotal role in DNA replication, transcriptional activation, and RNA-mediated gene silencing. It unwinds DNA and RNA in a 3' to 5' direction, essential for various biological processes. This protein also acts as a transcriptional coactivator, linking polymerase II holoenzyme with transcription factors, and is involved in the regulation of circadian rhythms and nuclear export of mRNA.
Therapeutic significance:
Understanding the role of ATP-dependent RNA helicase A could open doors to potential therapeutic strategies.