Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q08462
UPID:
ADCY2_HUMAN
Alternative names:
ATP pyrophosphate-lyase 2; Adenylate cyclase type II; Adenylyl cyclase 2
Alternative UPACC:
Q08462; B7Z2C1; Q2NKL8; Q9UDB2; Q9UPU2
Background:
Adenylate cyclase type 2, also known as ATP pyrophosphate-lyase 2 or Adenylyl cyclase 2, plays a pivotal role in cellular signaling by catalyzing the formation of cAMP in response to G-protein signaling. This enzyme is integral in downstream signaling cascades that alter gene expression patterns, notably increasing IL6 production. It also functions in pathways downstream of the muscarinic acetylcholine receptors.
Therapeutic significance:
Understanding the role of Adenylate cyclase type 2 could open doors to potential therapeutic strategies. Its involvement in critical signaling pathways highlights its potential as a target for modulating immune responses and inflammatory processes.