Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q0P5N6
UPID:
ARL16_HUMAN
Alternative names:
-
Alternative UPACC:
Q0P5N6
Background:
ADP-ribosylation factor-like protein 16 plays a crucial role in cellular processes by potentially suppressing the RNA sensing activity of RIGI in a GTP-dependent manner. This protein, pivotal in the regulation of intracellular signaling pathways, showcases the intricate balance of cellular responses to external stimuli.
Therapeutic significance:
Understanding the role of ADP-ribosylation factor-like protein 16 could open doors to potential therapeutic strategies. Its involvement in key cellular mechanisms makes it a promising target for drug discovery, aiming to modulate immune responses and possibly other pathways yet to be fully explored.