Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q0VF96
UPID:
CGNL1_HUMAN
Alternative names:
Junction-associated coiled-coil protein; Paracingulin
Alternative UPACC:
Q0VF96; Q05BZ4; Q52LR0; Q695C7; Q7Z2L3; Q96JV2; Q96MN6; Q9C0B4
Background:
Cingulin-like protein 1, also known as Junction-associated coiled-coil protein and Paracingulin, plays a crucial role in cellular structure by potentially anchoring the apical junctional complex, particularly tight junctions, to the actin-based cytoskeleton. This protein's involvement in cellular architecture underscores its importance in maintaining cellular integrity and function.
Therapeutic significance:
Cingulin-like protein 1's association with Aromatase excess syndrome, a disorder resulting from increased extraglandular aromatization of steroids, highlights its therapeutic significance. Understanding the role of Cingulin-like protein 1 could open doors to potential therapeutic strategies for managing conditions related to aberrant steroid aromatization.