Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q12904
UPID:
AIMP1_HUMAN
Alternative names:
Multisynthase complex auxiliary component p43
Alternative UPACC:
Q12904; B3KTR2; B4E1S7; Q6FG28; Q96CQ9
Background:
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1, also known as the multisynthase complex auxiliary component p43, plays a pivotal role in protein synthesis and various cellular processes. It is involved in the stimulation of cytoplasmic arginyl-tRNA synthase activity, tRNA binding, and possesses inflammatory cytokine activity. Additionally, it has a significant role in glucose homeostasis, wound repair, angiogenesis, and the modulation of endothelial cell responses.
Therapeutic significance:
The protein's involvement in hypomyelinating leukodystrophy, a severe neurological disorder, underscores its therapeutic potential. Understanding the role of Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 could open doors to potential therapeutic strategies for treating this debilitating condition.