Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q13117
UPID:
DAZ2_HUMAN
Alternative names:
-
Alternative UPACC:
Q13117; Q2KHN6; Q96P41; Q9NR91
Background:
Deleted in azoospermia protein 2 (DAZ2) plays a pivotal role in male fertility, acting as an RNA-binding protein essential for spermatogenesis. It specifically binds to the 3'-UTR of mRNAs, regulating their translation and ensuring proper sperm development.
Therapeutic significance:
DAZ2 is directly linked to Spermatogenic failure Y-linked 2, a condition marked by reduced or absent sperm in semen, leading to male infertility. Understanding the role of DAZ2 could open doors to potential therapeutic strategies for treating male infertility.