Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q13144
UPID:
EI2BE_HUMAN
Alternative names:
eIF-2B GDP-GTP exchange factor subunit epsilon
Alternative UPACC:
Q13144; Q541Z1; Q96D04
Background:
The Translation initiation factor eIF-2B subunit epsilon, also known as eIF-2B GDP-GTP exchange factor subunit epsilon, plays a pivotal role in protein synthesis. It catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP, a critical step in the initiation of translation. This protein's function is essential for the regulation of protein synthesis, impacting cellular growth and response to stress.
Therapeutic significance:
Leukoencephalopathy with vanishing white matter 5, a devastating brain disease, is directly linked to mutations in the gene encoding this protein. The disease manifests with progressive cerebellar ataxia, spasticity, cognitive deficits, and in severe cases, ovarian dysfunction in females. Understanding the role of Translation initiation factor eIF-2B subunit epsilon could open doors to potential therapeutic strategies for this and related neurological disorders.