Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q13164
UPID:
MK07_HUMAN
Alternative names:
Big MAP kinase 1; Extracellular signal-regulated kinase 5
Alternative UPACC:
Q13164; Q16634; Q59F50; Q6QLU7; Q7L4P4; Q969G1; Q96G51
Background:
Mitogen-activated protein kinase 7 (MAPK7), also known as Big MAP kinase 1 and Extracellular signal-regulated kinase 5, is pivotal in cellular processes including proliferation, differentiation, and survival. It is activated by MAP2K5, leading to nuclear translocation and phosphorylation of targets like MEF2C. MAPK7's activation via EGF occurs through a Ras-independent, MAP2K5-dependent pathway, playing roles in muscle differentiation, endothelial function, and blood vessel integrity.
Therapeutic significance:
Understanding the role of Mitogen-activated protein kinase 7 could open doors to potential therapeutic strategies.