Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries for protein-protein interfaces.
Fig. 1. The sreening workflow of Receptor.AI
It features thorough molecular simulations of the target protein, both isolated and in complex with key partner proteins, complemented by ensemble virtual screening that accounts for conformational mobility in the unbound and complex states. The tentative binding sites are explored on the protein-protein interaction interface and at remote allosteric locations, encompassing the entire spectrum of potential mechanisms of action.
Key features that set our library apart include:
partner
Reaxense
upacc
Q13241
UPID:
KLRD1_HUMAN
Alternative names:
KP43; Killer cell lectin-like receptor subfamily D member 1; NK cell receptor
Alternative UPACC:
Q13241; O43321; O43773; Q9UBE3; Q9UEQ0
Background:
Natural killer cells antigen CD94, also known as KP43, plays a crucial role in immune surveillance. As a part of the immune receptor complex with KLRC1 or KLRC2, it recognizes HLA-E molecules carrying peptides from MHC class I molecules, facilitating self-nonself discrimination. This process is vital for the immune system's ability to detect and respond to unhealthy cells while sparing normal ones.
Therapeutic significance:
Understanding the role of Natural killer cells antigen CD94 could open doors to potential therapeutic strategies. Its involvement in immune regulation and self-tolerance mechanisms highlights its potential as a target for modulating immune responses in diseases.