Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q13263
UPID:
TIF1B_HUMAN
Alternative names:
E3 SUMO-protein ligase TRIM28; KRAB-associated protein 1; KRAB-interacting protein 1; Nuclear corepressor KAP-1; RING finger protein 96; RING-type E3 ubiquitin transferase TIF1-beta; Tripartite motif-containing protein 28
Alternative UPACC:
Q13263; O00677; Q7Z632; Q93040; Q96IM1
Background:
Transcription intermediary factor 1-beta (TIF1-beta), also known as TRIM28, plays a pivotal role in gene silencing and transcriptional regulation. It functions as a nuclear corepressor for KRAB domain-containing zinc finger proteins, mediating gene silencing by recruiting various components like CHD3 and SETDB1 to promoter regions. TIF1-beta is involved in enhancing transcriptional repression, coordinating histone modification, and playing roles in cellular processes such as apoptosis prevention and transcriptional activation.
Therapeutic significance:
Understanding the role of Transcription intermediary factor 1-beta could open doors to potential therapeutic strategies.