Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q13415
UPID:
ORC1_HUMAN
Alternative names:
Replication control protein 1
Alternative UPACC:
Q13415; D3DQ34; Q13471; Q5T0F5
Background:
Origin recognition complex subunit 1 (ORC1) is a pivotal component of the origin recognition complex, crucial for the initiation of DNA replication. It binds to origins of replication in an ATP-dependent manner, although the specific DNA sequences recognized remain unidentified. This protein plays a key role in assembling the pre-replication complex necessary for DNA synthesis to commence.
Therapeutic significance:
ORC1's involvement in Meier-Gorlin syndrome 1, characterized by growth retardation and skeletal anomalies, underscores its potential as a therapeutic target. Understanding ORC1's function could lead to novel strategies for managing this syndrome.