Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q13523
UPID:
PRP4B_HUMAN
Alternative names:
PRP4 kinase; PRP4 pre-mRNA-processing factor 4 homolog
Alternative UPACC:
Q13523; A8K5C9; Q5D0F6; Q5TAY8; Q8IVC3; Q8TDP2; Q96QT7; Q9UEE6
Background:
Serine/threonine-protein kinase PRP4 homolog, known as PRP4 kinase, plays a crucial role in pre-mRNA splicing by phosphorylating SF2/ASF. This protein, with alternative names including PRP4 pre-mRNA-processing factor 4 homolog, is pivotal in the regulation of spliceosome dynamics.
Therapeutic significance:
Understanding the role of Serine/threonine-protein kinase PRP4 homolog could open doors to potential therapeutic strategies. Its involvement in pre-mRNA splicing presents a unique target for modulating gene expression in disease states.