Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q13586
UPID:
STIM1_HUMAN
Alternative names:
-
Alternative UPACC:
Q13586; E9PQJ4; Q8N382
Background:
Stromal interaction molecule 1 (STIM1) is pivotal in mediating store-operated Ca(2+) entry (SOCE), crucial for various cellular functions. It acts as a Ca(2+) sensor in the endoplasmic reticulum, translocating to the plasma membrane upon Ca(2+) depletion to activate the CRAC channel subunit ORAI1. STIM1 is also involved in enamel formation, highlighting its diverse biological roles.
Therapeutic significance:
STIM1 is linked to Immunodeficiency 10, Myopathy, tubular aggregate, 1, and Stormorken syndrome, diseases characterized by immune disorders, myopathy, and bleeding tendencies. Understanding STIM1's role could lead to novel therapeutic strategies for these conditions.