Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q13616
UPID:
CUL1_HUMAN
Alternative names:
-
Alternative UPACC:
Q13616; D3DWG3; O60719; Q08AL6; Q8IYW1
Background:
Cullin-1 is a core component of the cullin-RING-based SCF E3 ubiquitin-protein ligase complexes, crucial for ubiquitination in cell cycle progression, signal transduction, and transcription. It acts as a scaffold, organizing the SKP1-F-box protein and RBX1 subunits, and is essential for the ubiquitination of key proteins in Wnt signaling and G1/S transition among others.
Therapeutic significance:
Understanding the role of Cullin-1 could open doors to potential therapeutic strategies.