Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q13620
UPID:
CUL4B_HUMAN
Alternative names:
-
Alternative UPACC:
Q13620; B1APK5; B3KVX4; B7Z5K8; Q6PIE4; Q6UP07; Q7Z673; Q9BY37; Q9UEB7; Q9UED7
Background:
Cullin-4B, a core component of cullin-RING-based E3 ubiquitin-protein ligase complexes, plays a pivotal role in the ubiquitination and proteasomal degradation of target proteins. Its involvement in DNA damage response, cell cycle regulation, and the mTOR pathway underscores its multifaceted role in cellular processes.
Therapeutic significance:
Cullin-4B's mutation is linked to Intellectual developmental disorder, X-linked, syndromic, Cabezas type, highlighting its critical role in neurological development. Understanding Cullin-4B's functions could pave the way for innovative treatments for this disorder and potentially other related conditions.