Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q13888
UPID:
TF2H2_HUMAN
Alternative names:
Basic transcription factor 2 44 kDa subunit; General transcription factor IIH polypeptide 2; TFIIH basal transcription factor complex p44 subunit
Alternative UPACC:
Q13888; Q15570; Q15571; Q9BS41
Background:
General transcription factor IIH subunit 2 (GTF2H2) is a pivotal component of the TFIIH core complex, playing a crucial role in DNA repair and RNA transcription. It facilitates nucleotide excision repair (NER) by opening DNA around lesions for repair and is essential for transcription initiation by RNA polymerase II. GTF2H2's interaction with XPD and the importance of its C-terminus for promoter escape highlight its multifunctional nature.
Therapeutic significance:
Understanding the role of General transcription factor IIH subunit 2 could open doors to potential therapeutic strategies.