Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q14011
UPID:
CIRBP_HUMAN
Alternative names:
A18 hnRNP; Glycine-rich RNA-binding protein CIRP
Alternative UPACC:
Q14011; B3KT17; B4E2X2
Background:
The Cold-inducible RNA-binding protein, also known as A18 hnRNP or Glycine-rich RNA-binding protein CIRP, plays a pivotal role in the cellular response to cold stress. It stabilizes transcripts of genes crucial for cell survival, acting as a translational activator, and is essential in cold-induced suppression of cell proliferation. This protein binds specifically to the 3'-UTRs of stress-responsive transcripts such as RPA2 and TXN, promoting the assembly of stress granules.
Therapeutic significance:
Understanding the role of Cold-inducible RNA-binding protein could open doors to potential therapeutic strategies.