Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q14166
UPID:
TTL12_HUMAN
Alternative names:
Inactive tubulin--tyrosine ligase-like protein 12
Alternative UPACC:
Q14166; Q20WK5; Q9UGU3
Background:
Tubulin--tyrosine ligase-like protein 12, also known as Inactive tubulin--tyrosine ligase-like protein 12, plays a crucial role in cellular processes. It negatively regulates post-translational modifications of tubulin and indirectly promotes histone H4 trimethylation, impacting mitosis and chromosome number stability. Additionally, it acts as a negative regulator of the RIG-I pathway during RNA virus-mediated infection.
Therapeutic significance:
Understanding the role of Tubulin--tyrosine ligase-like protein 12 could open doors to potential therapeutic strategies. Its involvement in key cellular processes and virus-mediated infection response highlights its potential as a target for drug discovery.