Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q14181
UPID:
DPOA2_HUMAN
Alternative names:
DNA polymerase alpha 70 kDa subunit
Alternative UPACC:
Q14181; B4DNB4; Q9BPV3
Background:
The DNA polymerase alpha subunit B, also known as the DNA polymerase alpha 70 kDa subunit, is a crucial component of the DNA polymerase alpha complex. This complex is essential for the initiation of DNA synthesis during the S phase of the cell cycle. It is composed of a catalytic subunit POLA1, an accessory subunit POLA2, and two primase subunits, PRIM1 and PRIM2. The complex is recruited to DNA at replicative forks, initiating DNA synthesis by oligomerizing short RNA primers on both leading and lagging strands.
Therapeutic significance:
Understanding the role of DNA polymerase alpha subunit B could open doors to potential therapeutic strategies.