Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q14320
UPID:
FA50A_HUMAN
Alternative names:
Protein HXC-26; Protein XAP-5
Alternative UPACC:
Q14320; A8KAQ4; B2R997; Q5HY37; Q6PJH5
Background:
Protein FAM50A, also known as Protein HXC-26 and Protein XAP-5, plays a crucial role in the regulation of pre-mRNA splicing. This process is fundamental for the correct expression of genes, impacting cellular function and organism development.
Therapeutic significance:
Linked to Intellectual developmental disorder, X-linked, syndromic, Armfield type, FAM50A's dysfunction showcases the protein's critical role in neurological development. Understanding the role of Protein FAM50A could open doors to potential therapeutic strategies for this disorder.