Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q14558
UPID:
KPRA_HUMAN
Alternative names:
39 kDa phosphoribosypyrophosphate synthase-associated protein
Alternative UPACC:
Q14558; B2R6M4; Q96H06
Background:
Phosphoribosyl pyrophosphate synthase-associated protein 1, also known as the 39 kDa phosphoribosypyrophosphate synthase-associated protein, plays a crucial role in cellular metabolism. It is involved in the synthesis of 5-phosphoribose 1-diphosphate, a key precursor in the biosynthesis of nucleotides and nucleic acids.
Therapeutic significance:
Understanding the role of Phosphoribosyl pyrophosphate synthase-associated protein 1 could open doors to potential therapeutic strategies. Its involvement in nucleotide biosynthesis pathways suggests its potential impact on cellular proliferation and survival, making it a target of interest in cancer research and treatment.