Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q14566
UPID:
MCM6_HUMAN
Alternative names:
p105MCM
Alternative UPACC:
Q14566; B2R6H2; Q13504; Q99859
Background:
DNA replication licensing factor MCM6, also known as p105MCM, is a pivotal component of the MCM2-7 complex, the replicative helicase necessary for DNA replication initiation and elongation in eukaryotic cells. It forms a core part of the CDC45-MCM-GINS helicase, unwinding DNA during replication. The MCM2-7 ring's ATPase active sites, essential for helicase activity, are formed through the interaction of neighboring subunits.
Therapeutic significance:
Understanding the role of DNA replication licensing factor MCM6 could open doors to potential therapeutic strategies.