Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q14596
UPID:
NBR1_HUMAN
Alternative names:
Cell migration-inducing gene 19 protein; Membrane component chromosome 17 surface marker 2; Neighbor of BRCA1 gene 1 protein; Protein 1A1-3B
Alternative UPACC:
Q14596; Q13173; Q15026; Q5J7Q8; Q96GB6; Q9NRF7
Background:
Next to BRCA1 gene 1 protein, known by alternative names such as Cell migration-inducing gene 19 protein and Neighbor of BRCA1 gene 1 protein, plays a pivotal role in cellular processes. It is a key player in ubiquitin-binding autophagy, aiding in host defense and maintaining intracellular homeostasis. This protein is instrumental in selective autophagy, serving both as a shuttle for ubiquitinated proteins to autophagosomes and in protein aggregate formation. It also regulates the innate immune response by influencing type I interferon production and targeting IRF3 for autophagic degradation.
Therapeutic significance:
Understanding the role of Next to BRCA1 gene 1 protein could open doors to potential therapeutic strategies.