Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q14651
UPID:
PLSI_HUMAN
Alternative names:
Intestine-specific plastin
Alternative UPACC:
Q14651; A8K2Q1; D3DNG3; Q8NEG6
Background:
Plastin-1, also known as Intestine-specific plastin, plays a pivotal role in the inner ear by bundling actin filaments. This process is crucial for the formation of stereocilia, which are essential for hearing. The protein's ability to mediate liquid packing of actin filaments ensures stereocilia reach their proper dimensions, highlighting its significance in auditory function.
Therapeutic significance:
Given its critical role in stereocilia formation, Plastin-1 is directly linked to Deafness, autosomal dominant, 76, a condition characterized by sensorineural hearing loss. Understanding the role of Plastin-1 could open doors to potential therapeutic strategies for treating hearing loss and preventing its progression.