Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q14694
UPID:
UBP10_HUMAN
Alternative names:
Deubiquitinating enzyme 10; Ubiquitin thioesterase 10; Ubiquitin-specific-processing protease 10
Alternative UPACC:
Q14694; B2RDJ8; B4DS84; Q9BWG7; Q9NSL7
Background:
Ubiquitin carboxyl-terminal hydrolase 10 (USP10) is a versatile enzyme with key roles in protein stability and cellular stress responses. It selectively deubiquitinates target proteins such as p53/TP53, enhancing their stability, and plays a crucial role in autophagy regulation by stabilizing BECN1. USP10 also facilitates 40S ribosome subunit recycling, preventing stress granule formation and promoting efficient protein synthesis.
Therapeutic significance:
Understanding the role of Ubiquitin carboxyl-terminal hydrolase 10 could open doors to potential therapeutic strategies. Its involvement in p53/TP53 stability, autophagy, and ribosome recycling highlights its potential as a target in cancer therapy and diseases related to protein misfolding and degradation.