Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q15013
UPID:
MD2BP_HUMAN
Alternative names:
Caught by MAD2 protein; p31(comet)
Alternative UPACC:
Q15013; B4DLV3; E9PAT7; Q6IBB1
Background:
The MAD2L1-binding protein, also known as Caught by MAD2 protein or p31(comet), plays a crucial role in cell cycle regulation. It is instrumental in silencing the spindle checkpoint to facilitate the progression of mitosis through anaphase by interacting with MAD2L1 once it is released from the MAD2L1-CDC20 complex. This interaction is vital for the accurate segregation of chromosomes during cell division.
Therapeutic significance:
Understanding the role of MAD2L1-binding protein could open doors to potential therapeutic strategies. Its pivotal function in cell cycle regulation highlights its potential as a target for developing treatments aimed at controlling cell proliferation, which is a fundamental aspect of cancer biology.